Inherited dyslipidaemic disorders contributing to coronary heart disease

ABSTRACT

Lipoprotein [a] [Lp [a]] is an established independent risk factor for premature myocardial infarction [MI]/coronary artery disease [CAD]. The study was conducted to determine the value of Lp [a] in prediction of CAD or MI in the offspring at risk. A total of 160 subjects were investigated. Serum Lp [a] was measured by ELISA, serum total cholesterol, triglycerides [TG] and HDL-Cholesterol by enzymatic colorimetric methods using standard kits. Differences in levels of total Lp [a] and cholesterol were observed between patients and controls. Both Lp [a] [16.23 +/- 1.95 mg/dL] and cholesterol [175.00 +/- 7.60 mg/dL] of group A [patients] were higher than the corresponding controls. However an opposite trend in results was noted for serum HDL-Cholesterol in patients vs. controls. Persons found to have elevated levels of Lp [a] should focus on controlling the known modifiable risk factor for heart disease, especially smoking, hypercholesterolemia, obesity, hypertension and sedentary life style