[Interaction between JWH133-induced antinociception and two extreme doses of celecoxib]

ABSTRACT

JWH133 is known to have cannabinoid-2 [CB2] receptor agonist properties. Celecoxib, a selective cyclooxygenase-2 [COX-2] inhibitor, is also known to have antinociceptive properties. Endocannabinoids produce analgesia possibly through cyclooxygenase [COX] pathway. The aim of the present work was to study the effect of celecoxib on JWH133 induced antinociception and to compare the effects of two different dose ranges of celecoxib [mg/kg and nano g/kg] on the JWH133 antiniciceptive effect. We have studied the possible interaction of administration of mg/kg [50-200 mg/kg] and Ultra-Low Dose [ULD] [25 and 50 ng/kg] of celecoxib on the antinociceptive effect of intraperitoneal [i.p.] injection of JWH133 using formalin test in mice. JWH133 [0.01, 0.1 and 1 mg/kg] induced antinociceptive effect just in phase I of the formalin test. Celecoxib [50-200 mg/kg] and its ULD [25 and 50 ng/kg] attenuated and potentiated, JWH133 induced antinociception, respectively. It is concluded that JWH-133 induced antinociception is modulated by celecoxib and mg/kg doses of celecoxib showed opposite effects compare to its ultra-low doses