Lung cancer stem cells research. Clues from ontogeny
Saudi Medical Journal. 2009; 30 (11): 1381-1389
in English
| IMEMR
| ID: emr-102325
ABSTRACT
Cancer stem cell [CSC] hypothesis provides us with a new approach to the understanding of carcinogenesis, therapeutics, and prevention strategies. In recent years, the origin and biological characteristics of CSC were widely studied in solid tumors; it is astonishing to find out the delicate relevancy between CSC and committed progenitors evolved from embryonic stem cells [ESC] during organ development. In this review, we propose that some key molecular signal pathways during lung development are crucial for abnormal self-renewal and differentiation of lung cancer stem cell as well as try to elaborate the lung CSCs from the point view of ontogeny
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Research Design
/
Neoplastic Stem Cells
/
Signal Transduction
/
Gene Expression Regulation, Neoplastic
/
Cell Transformation, Neoplastic
/
Cytogenetic Analysis
/
Cell Line, Tumor
/
Cell Proliferation
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Saudi Med. J.
Year:
2009
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