Pharmacological evaluation of smaller chain di- and tri-peptides in alloxan-induced rabbits

ABSTRACT

Amino acids and smaller chain peptides form an integral part of body's inventory of drugs which maintain the various functions, vital to human life and health. Test drugs such as Ile-Val, Ile-Val-Glu and Gly-Phe showed significant anti-diabetic activity, with Ile-Val being most effective amongst all using insulin as a standard drug. Statistical analysis showed that test drug possessed significant antidiabetic activity [t-value at P<0.01=4.02]. The smaller chain peptide combinations are showing significant anti-diabetic activity due to better physical and chemical stability in comparison with the long chain peptide combinations of the standard insulin