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C1 Inhibitor, C3 activator, IgG, IgA, and IgM titers in Nigerian sickle cell disease patients with plasmodium falciparum
IJI-Iranian Journal of Immunology. 2007; 4 (1): 44-49
in English | IMEMR | ID: emr-102543
ABSTRACT
Sickle cell disease [HbSS] is a major health problem in Nigeria and malaria has been implicated as a leading cause of morbidity/mortality in sickle cell disease patients. Few reasons were put forward to explain the observed morbidity/mortality of HbSS subjects due to Plasmodium falciparum [P. falciparum] malaria. To determine the level of immunoglobulin classes [IgM, IgA, and IgG] and regulators of complement system [C1 inhibitor and C3 activator] in Nigerian HbSS patients with and without P. falciparum parasitemia. A total of 64 subjects were considered, including 10 HbSS genotypic subjects with P. falciparum parasitemia [HbSS+PfM], 18 HbAA genotypic subjects with P. falciparum parasitemia [HbAA+PfM], 20 HbSS without P. falciparum parasitemia [HbSS-PfM], and 16 HbAA genotypic subjects without P. falciparum parasitemia [HbAA-PfM]. IgM, IgA, IgG, C1 inhibitor, and C3 activator titers were quantified by single radial immunodiffusion method. The mean levels of IgG in HbSS+PfM [2373.90 +/- 1772.81mg/dl] and HbAA+PfM [1868.80 +/- 0.00mg/dl] were significantly higher compared with HbSS-PfM [644.55 +/- 171.15mg/dl] or HbAA-PfM [659.75 +/- 158.01mg/dl] patients. HbAA-PfM subjects had the lowest level of IgM [67.27 +/- 63.7mg/dl], though no significant difference was observed comparing mean levels of IgM between the four groups. IgA titer was significantly higher in HbSS-PfM patients [249.00 +/- 94.8mg/dl] compared with HbAA-PfM [p<0.05], HbAA+PfM [p<0.05], or HbSS+PfM [p<0.05]. The mean values of C1 inhibitor were lower in HbSS+PfM and HbAA+PfM compared with HbSS-PfM or HbAA-PfM. However, HbAA+PfM had a significantly lower value of C1 inhibitor compared with HbAA-PfM [p<0.01]. C3 activator was highest in HbSS-PfM [17.10 +/- 7.35mg/dl] and was significantly higher compared with HbSS+PfM [p<0.05]. Increased C1 inhibitor and decreased C3 activator in HbSS+PfM compared with HbAA+PfM shows that deranged regulation of complement factors may be responsible for increased susceptibility of HbSS to P. falciparum malaria
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Index: IMEMR (Eastern Mediterranean) Main subject: Plasmodium falciparum / Complement System Proteins / Immunoglobulin A / Immunoglobulin A, Secretory / Immunoglobulin G / Immunoglobulin M / Malaria, Falciparum / Complement C3-C5 Convertases / Complement C1 Inhibitor Protein / Malaria Limits: Humans Language: English Journal: Iran. J. Immunol. Year: 2007

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Index: IMEMR (Eastern Mediterranean) Main subject: Plasmodium falciparum / Complement System Proteins / Immunoglobulin A / Immunoglobulin A, Secretory / Immunoglobulin G / Immunoglobulin M / Malaria, Falciparum / Complement C3-C5 Convertases / Complement C1 Inhibitor Protein / Malaria Limits: Humans Language: English Journal: Iran. J. Immunol. Year: 2007