Perivascular epithelioid cell tumor [PEComa] of the uterus with aggressive behavior at presentation
Hematology, Oncology and Stem Cell Therapy. 2009; 2 (3): 426-430
in English
| IMEMR
| ID: emr-102598
ABSTRACT
Perivascular epithelioid cell tumor [PEComa] is a rare mesenchymal tumor composed of histologically and immunohistochemically distinctive perivascular epithelioid cells [PECs]. Both benign and malignant tumors have been identified, but the criteria for diagnosis of malignancy have not been fully established due to the rarity of the tumor. We report on a case of uterine PEComa in a 33-year old woman with lymph node metastasis at presentation. The tumor had the characteristic histologic features of PEComa with cytologic atypia, mitotic activity of 2/10 high power field [HPF], and necrosis; it exhibited immunopositivity for HMB-45, calponin and desmin and was negative for melan-A. The patient received neoadjuvant chemotherapy, debulking surgery and adjuvant chemotherapy. No evidence of recurrence or metastasis was apparent 8 months after surgery
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Uterine Neoplasms
/
Chemotherapy, Adjuvant
/
Perivascular Epithelioid Cell Neoplasms
Type of study:
Case report
Limits:
Female
/
Humans
Language:
English
Journal:
Hematol. Oncol. Stem Cell Ther.
Year:
2009
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