Gastrointestinal abnormalities in vitamin B[12] deficient patients with megaloblastic anemia
JCPSP-Journal of the College of Physicians and Surgeons Pakistan. 2009; 19 (10): 672-673
in English
| IMEMR
| ID: emr-102627
ABSTRACT
In a retrospective cohort study, hospital records of 220 patients [119 males and 101 females, age 1 year-80 years] with megaloblastic anemia were examined to find out any relationship of gastrointestinal abnormalities with vitamin B[12] and folate deficiencies in these patients. Forty three percent of the patients were folate-deficient [serum folate levels = 3.5 ng/ml], while 79% were vitamin B[12]-deficient [serum B[12] levels = 200 pg/ml]. Gastrointestinal abnormalities [gastritis, malabsorption and infection] in B[12]-deficient patients were marginally significant [p=0.05] compared to the abnormalities in B[12]-normal patients. Severe dyserythropoiesis was more common in vitamin B[12]-deficient and folate-deficient patients compared to B[12]-normal and folate-normal patients. However, the proportions were not statistically significant. Marginally significant occurrence of gastrointestinal abnormalities in vitamin B[12]-deficient subjects points towards the notion that poor dietary intake along with poor gut absorption could be contributing to the high prevalence of vitamin B[12] deficiency in this population
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Retrospective Studies
/
Cohort Studies
/
Gastrointestinal Tract
/
Folic Acid
/
Gastrointestinal Diseases
/
Anemia, Megaloblastic
Type of study:
Incidence study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
J. Coll. Physicians Surg. Pak.
Year:
2009
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