[Topiramate associated bilateral acute angle closure glaucoma and myopia]

ABSTRACT

Topiramate, is an oral Sulfonamide medication that was primarily licensed for treating epilepsy, though increasingly used for treating migraine. In recent years there have been several reports of its association with bilateral acute angle closure glaucoma and or myopia. We introduce a rare case of simultaneous bilateral acute angle closure glaucoma and myopia following topiramate usage. A 43 years-old woman, who referred to Amiralmomenin hospital with bilateral painful visual loss following prescription of topiramate. Her best corrected visual acuity was one meter counting finger in both eyes. Intraocular pressure was 60 mm Hg OD and 54 mm Hg OS with ciliary injection. There were corneal edema, shallow anterior chamber and closed angles on gonioscopy in both eyes. Abnormal findings were normalized within 2 weeks after discontinuation of topiramate and starting antiglaucoma medication. Topiramate can caused acute bilateral angle- closure glaucoma and myopia, which is usually reversible and its intraocular pressure is controlled promptly by discontinuing drug. Patients who started Topiramate therapy need to be informed of this potential risk especially within first few weeks after starting or increasing dose of the drug