[Efficacy and safety of herbal drug, Hypericum perforatum in the treatment of premature ejaculation]

ABSTRACT

Premature ejaculation is the most prevalent form of male sexual dysfunction. Efforts to develop novel drugs safer than existing therapies are continued. Assessment of efficacy of Hypericum Perforatum in the treatment of premature ejaculation. This is the double blind, randomized placebo- controlled study. In this study were selected 50 married men [18-50 years old] who were referred to urology department of Razi hospital in Rasht from 2007 to 2008 with premature ejaculation were selected. These patients were divided to control and cases groups. Hypericum [160mg tablets] were prescribed for case group and placebo for control group. All participants completed IIEF-15 questionnaire before and after treatment. Intra vaginal latency time [IVLT] was measured before and after treatment. The results were analyzed using chi-square and paired t-test. After 4 weeks, there was difference in IVLT between 2 groups. This difference was statically significant [P<0.001]. There was an increase in two variables of the IIEF-15 [Intercourse satisfaction and overall satisfaction] in hypericum perforatum group [p<0.001]. In 3 participants drug was discontinued because of adverse reactions. It seems that hypericum perforatum may be regarded as a safe and effective alternative in the treatment of premature ejaculation