[Plasma free 8-iso-PGF2alpha levels in normotensive and preeclamptic pregnancies]
Medical Sciences Journal of Islamic Azad University. 2009; 19 (1): 49-53
in Persian
| IMEMR
| ID: emr-103296
ABSTRACT
Preeclampsia is a main cause of morbidity and mortality of pregnant women worldwide. Recently oxidative stress was considered as a part of pathophysiolgy of preeclamsia and 8-isc% prostaglandin F2alpha [8-iso-PGF2 alpha] is known as a marker of oxidative stress. The purpose of this study was to measure and compare plasma concentration of free 8-iso-PG F2 alpha in women with normotensive and preeclamptic pregnancies. In this descriptive-analytic study, Plasma free 8-iso-PGF2 alpha levels were measured in pregnant women with preeclamsia [n=42] and normotensive pregnant women [n=39] between 28-38 weeks of gestation. Women in two groups were matched in age, gestational age and socioeconomic statue and all women were nulligravid. Free 8-iso-PGF2 alpha levels were not significantly different in women with preeclamsia and normotensive group [17808 vs. 24288 pg/dl, NS]. Plasma free 8-iso-PGF2 alpha levels were increased in severe compared to mild preeclampsia [NS]. Neonates weight of preeclamptic mothers was significantly lower than neonates of normotensive women [p<0.0001]. Although free 8-iso-PGF2 alpha is a marker of oxidative stress in vitro, but its measurement is not valuable in clinical medicine. However, further studies in normal pregnancy and preeclampsia will be needed
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Pre-Eclampsia
/
Pregnancy
/
Dinoprost
Limits:
Female
/
Humans
Language:
Persian
Journal:
Med. Sci. J. Islam. Azad Univ.
Year:
2009
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