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Novel synthesis of furoindole pyridone, pyrazolone and cyanoacethydrazide derivatives from isatin
Egyptian Journal of Pharmaceutical Sciences. 1988; 29 (1-4): 419-25
in English | IMEMR | ID: emr-10344
Responsible library: EMRO
ABSTRACT
Isatin I reacted with diethyl 2-amino-1-cyanopropen-1,3-dicarboxylate IIa and with 1,1-dicyano-3-carbethoxy-2-aminoprop-1-ene IIb to give the corresponding 3-substituted furoindole derivatives IV. Compound IVa reacted with malononitrile and ethylcyanoacetate to give the 3- substituted-pyridine and pyridone derivatives VI and VIII, respectively. The reaction of isatin with cyanoacethydrazine afforded IX which was cyclised to aminopyrazolone derivative X on boiling its solution in ethanol/triethylamine. Similarly, treatment of istain I with methylpyrazlinone afforded the corresponding derivative XII
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Index: IMEMR (Eastern Mediterranean) Main subject: Pyrazoles / Pyridines / Pyridones / Chemistry, Pharmaceutical Language: English Journal: Egypt. J. Pharm. Sci. Year: 1988

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Index: IMEMR (Eastern Mediterranean) Main subject: Pyrazoles / Pyridines / Pyridones / Chemistry, Pharmaceutical Language: English Journal: Egypt. J. Pharm. Sci. Year: 1988