[Triglyceride/HDL- cholesterol ratio [TG/HDL- C] beside the total cholesterol is a predictor for coronary heart disease in an Iranian men population]

ABSTRACT

Triglyceride/HDL-cholesterol ratio [TG/HDL-C] has been shown as an indicator for metabolic syndrome [MetS]. This study aimed to detect the role of this ratio to predict coronary heart disease [CHD] outcome in an Iranian men population with high prevalence of MetS. 1824 men >/= 40 years old, free of clinical cardiovascular disease at baseline, were included in the study from February 1999 to August 2001. Serum level of total cholesterol [TC], HDL-C, TG, and risk factors of CHD; including age, systolic blood pressure, diastolic blood pressure, body mass index, diabetes, smoking and family history of cardiovascular diseases were measured at initial phase of study. During a median follow up of 6.5 years until March 2007, a total of 163 new CHD events occurred. According to a Cox proportional hazard modeling, after adjustment for TC and other risk factors, men in the top quartile of TG/HDL-C relative to first quartile had a significant hazard ratio [HR] of 1.85 [95% Cl, 1.07-3.17]. Combined HR for TC and TG/HDL-C [men in the top quartiles of both TC and TG/HDL-C relative to first quartiles] after adjustment for other risk factors was 6.13 [95% Cl, 2.37-15.86]. The evaluation of both TG/HDL-C ratio and TC should be considered for CHD risk prediction in Iranian male population