Some novel 2-substituted amino-3-heteroaryl-pyridines as potential antimicrobial agents

ABSTRACT

Compounds having the general formulae [VI] and [IX] have been efficiently prepared from 2-arylaminonicotinic acid hydrazide IV. Group VI was prepared by the condensation of IV with various carbonyl compounds to give the arylidene hydrazides V, which underwent cyclization to the corresponding oxadizolines VI with acctic anhydride. Additionally, compounds VIII, obtained through cyclization of the corresponding thiosemicarbazide VII, were reacted with 1,2- dibromoethane giving the thiazolo [3 2-b]-s- triazoie derivatives IX. Seven compounds were subjected in vitro testing and most of them exhibit noticeable antibacterial activity