Novel thienyl-substituted pyridone and pyridine derivatives, synthesis and antimicrobial activity
Egyptian Journal of Pharmaceutical Sciences. 1988; 29 (1-4): 553-61
in English
| IMEMR
| ID: emr-10361
ABSTRACT
A novel series of thienyl-substituted pyridone and pyridine derivatives was synthesized. Treatment of arylidene alpha- acetothienones [I] with ethyl cyanoacetate afforded thienyl substituted cyanodihydropyridones [II] or cyanopyridones [III] depending on the reaction conditions. Likewise, reacting the same chalcone analogues [I] with malononitrile yielded thienyl substitued cyanoaminodihydropyridines [IV] or pyridines [V]. Some of the prepared compounds showed antimicrobial activity against S. aureus and M. phllei
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Pyridines
/
Antibiosis
Language:
English
Journal:
Egypt. J. Pharm. Sci.
Year:
1988
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