Lipid profile and serum insulin levels in gastational diabetes

ABSTRACT

To evaluate the glucose intolerance, insulin, and lipid profile in women who developed gestational Diabetes, compared to healthy pregnancy. Observational study. One hundred pregnant women, 50 healthy as control group and 50 already diagnosed gestational diabetic women as study group were selected. Plasma fasting [FBS] and post prandial glucose [RBS], serum insulin and serum lipid profile [total lipids, cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol] of both were monitored. Mean values were compared using t-test. Mean FBS [124.76 +/- 4.22 vs. 90.06 +/- 1.20 mg/dl], mean RBS [221.38 +/- 6.68 vs. 120.32 +/- 1.97 mg/dl], insulin [32.10 +/- 0.83 vs. 17.88 +/- 0.54 micro IU/ml], mean cholesterol [216.60 +/- 5.87 vs. 166.38 +/- 3.19 mg/dl], mean triglycerides [189.36 +/- 6.76 vs. 106.28 +/- 2.85 mg/dl], LDL-cholesterol [131.08 +/- 4.73 vs. 102.48 +/- 2.18 mg/dl] and total lipids [825.24 +/- 16.92 vs. 653.96 +/- 15.40 mg/dl] were higher in GDM groups as compared to normal controls [p<0.01]. Mean HDL-cholesterol [41.24 +/- 0.65 vs. 48.34 +/- 0.66 mg/dl] showed significantly lower concentration in GDM group as compared to controls [p<0.01]. Mean insulin and lipid levels, except HDL-cholesterol, were significantly higher in gestational diabetics compared to controls