Neuronal cortical migration disorder associated with epilepsy in Sudanese male twins: a case report and literature review

ABSTRACT

Epilepsy is the most common neurological disorder affecting young people. The aetiologies are multiple and most cases are sporadic. Disturbances of neuroblast migration and consequently abnormal development of the human cortex and genetic malformations are recognized as significant causes of mental retardation, symptomatic epilepsy and congenital neurologic deficits with abnormal neurological development in children. This review will discuss two male twins with cortical malformation and epileptic seizures failure to thrive, microcephaly and global developmental delay. The classical fades of Miller-Dieker syndrome are not present. The family history suggested a hereditary disorder of XL type