efficacy of a 1-week triple therapy for eradication of Helicobacter pylori infection in children

ABSTRACT

Poor compliance to therapy and antibiotic resistance are the main causes for failure of anti-Helicobacter pylori [H. pylori] therapy. The purpose of this study was to assess the effectiveness of omeprazole-based triple therapy in Iranian children. Fifty-seven children with H. pylori-related gastroduodenal disease received 1-week triple therapy with a combination of omeprazole, amoxicillin and clarithromycin [according to the susceptibility test]. Success of eradication was assessed by [13]C-urea breath test and endoscopy. Sixty-four patients [mean age 11.3 years; range 2.7-16 years] were included. Eradication was successful in 84.2% [95% confidence interval, 72.8% intention to treat]. One-week triple therapy was effective for the eradication of H. pylori infection in children