Severe hepatotoxicity associated with the combination of spiramycin plus metronidazole
Arab Journal of Gastroenterology. 2011; 12 (1): 44-47
in English
| IMEMR
| ID: emr-104235
ABSTRACT
Drug-induced liver injury [DILI] is a leading cause of acute liver failure and is the most frequent reason for post-marketing drug withdrawal. The spectrum of liver injury is wide, ranging from mild and subclinical injury, noticeable only on routine biochemical testing, to fulminant liver failure and death. Antibiotics, as a group, are a leading cause of DILI. We herein describe 4 patients who developed moderate to severe hepatotoxicity after exposure to a commercially - available combination of two antibiotics - spiramycin and metronidazole -commonly used for the treatment and prevention of periodontal infections. No other aetiology for liver injury could be identified in all cases. Two patients recovered spontaneously, and two had a more severe course, one responding to corticosteroids and mycophenolate mofetil and the other requiring liver transplantation for subacute massive necrosis
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Index:
IMEMR (Eastern Mediterranean)
Language:
English
Journal:
Arab J. Gastroenterol.
Year:
2011
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