Variation of adiponectin levels in normal and obese subjects: possible correlation with lipid profiles

ABSTRACT

Data available suggests that Adiponectin, an adipocyte-derived peptide, is associated with adiposity and could effect the regulation of glucose and lipid metabolism in humans. The aim of this study was to evaluate the association between serum adiponectin concentrations and anthropometric indices and lipid profiles among Iranian women with different grades of obesity. In this analytical descriptive study of 157 non-diabetic women [33 normal weight, BMI< 25 kg/m2 and 124 overweight and obese, BMI >/= 25kg/m2], serum adiponectin and leptin levels were measured using an enzyme-linked immunoassay. Fasting glucose and lipid profile levels determined by the glucose oxidize and enzymatic methods, respectively. Mean serum adiponectin concentration significantly decreased with obesity [p<0.05]. Although adiponectin showed a significant negative correlation with BMI [r=-0.321], it was correlated with serum leptin [r=-0.139], glucose [r=0.259], LDL-C [r=-0.125], TGs [r=-0.210] levels, TSF [r=-0.145], WHR [r=-0.159], and positively with serum HDL-C concentration [r=0.218] in all subjects [p<0.05]. Results of multiple regression analyses showed that adiponectin as a dependent variable had a significant correlation with BMI [beta =-0.605, P=0.017], waist circumference [beta =0.624, p=0.029], WHR [beta =-0.251, p=0.048], frame [beta =0.260, p=0.018], TC/HDL-C ratio [beta =-0.1.309, p=0.040] and LDL/HDL ratio [beta =-1.343, p=0.007] and changes in waist size had a significant effect on serum adiponectin levels. Our results suggested that adiponectin had an inverse correlation with adiposity indices and unfavorable lipid profiles, and that variation of waist circumference mostly affected Iranian women