Medical Principles and Practice. 2008; 17 (3): 255-257
in English
| IMEMR
| ID: emr-104586
ABSTRACT
To report a case with the diagnosis of IgM nephropathy and familial Mediterranean fever [FMF]. Clinical Presentation and Intervention A 9-year-old boy was admitted to our hospital with recurrent abdominal pain since the age of 4 years. Laboratory investigations revealed a sedimentation rate of 88 mm/h, C-reactive protein 83.2 mg/l [0-10 mg/l], white blood cell count 12,700/mm3, fibrinogen 622 mg/dl [200-400 mg/dl] and serum amyloid A 186 mg/l [0-5.8 mg/l]. Urinalysis revealed +2 proteinuria. A 24-hour urinary protein excretion was 12 mg/m2/h. M694V homozygous mutation was identified in exon 10. Percutaneous renal biopsy showed mesangial cell proliferation and increased mesangial matrix in the glomeruli, without amyloid accumulation. Immunofluorescence study showed IgM [+1] and C1q [+1] deposits. Treatment with 1 mg/day colchicine was started. Six weeks later, proteinuria had disappeared and the patient was asymptomatic. This case illustrates the unusual association of FMF with non-amyloid glomerulopathy. Glomerular diseases such as IgM nephropathy may be seen as a manifestation of FMF
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Familial Mediterranean Fever
/
Immunoglobulin M
/
Colchicine
/
Tubulin Modulators
/
Glomerulonephritis
Type of study:
Case report
Limits:
Humans
/
Male
Language:
English
Journal:
Med. Princ. Pract.
Year:
2008
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