[Cyclooxygenase; prevention and treatment]
Journal of the Faculty of Medicine-Shaheed Beheshti University of Medical Sciences and Health Services. 2007; 31 (3): 289-297
in Persian, English
| IMEMR
| ID: emr-104703
ABSTRACT
Cyclooxygenase [COX] is the key enzyme required for the conversion of arachidonic acid to prostaglandins. Two cycloxygenase isoforms have been identified and are referred to as COX-I and COX-2. Both enzymes are blocked by nonselective anti-inflammatory drugs [NSAID], such as indomethacin and ibuprofen. COX-I is an enzyme normally found in tissues and is involved in physiological functions, while COX-2 is an acute phase reactant associated with inflammation. Recently, COX-2 has been found to be associated with hyperalgesia, angiogenesis, cancer and Alzheimers disease. The suggestion that COX-2 is causally linked to cancer offers a new approach to extending our knowledge about the neoplastic phenomenon and improving management of human malignant diseases
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Prostaglandins
/
Anti-Inflammatory Agents, Non-Steroidal
/
Arachidonic Acid
/
Cyclooxygenase 1
/
Cyclooxygenase 2
/
Neoplasms
Language:
English
/
Persian
Journal:
J. Fac. Med.-Shaheed Beheshi Univ. Med. Sci. Health Serv.
Year:
2007
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