[Molecules and signaling pathways in transendothelial migration of leukocytes]

ABSTRACT

Transendothelial migration of leukocytes [diapedesis], have vital role in both the innate and adaptive immune responses. This process consists of overlapping steps, including activation of leukocytes, formation of weak adhesions, and translocation along the endothelium followed by stronger adhesions resulting in transmigration of leukocytes. Although the surface molecules used by leukocytes and endothelial cells during diapedesis have been well characterized, the mechanisms by which they regulate this process is poorly understood. In this mini review we introduce some of the involved molecules and mechanisms that play roles in this process