[Study of PAI-1 4G/5G polymorphism as a genetic risk factor for cardiovascular disease in the Iranian population]
Genetics in the 3rd Millennium. 2010; 8 (1): 1973-1977
in Persian
| IMEMR
| ID: emr-104805
ABSTRACT
Two hundred and eight asymptomatic individuals from different origins of Iran were included in this study in order to assess the distribution of the PAI-1 4G/5G polymorphism responding for cardiovascular disease [CVD] in the general Iranian population using a novel technique reverse hybridization Strip Assay for the rapid and simultaneous detection. The test is based on multiplex PCR and hybridization to a test strip presenting a parallel array of allele-specific oligonucleotide probes. The allele frequency of mutant PAI-1 4G/5G [0.45] is comparable to that of Europeans, but exceeded the much lower frequencies known from the most of Asia. Here we describe the distribution of mutant allele PAI-1 4G/5G in different ethnicities of Iranian population. Our data represent the only comprehensive study to date with respect to thrombophilic gene polymorphism in Iran
Search on Google
Index:
IMEMR (Eastern Mediterranean)
Language:
Persian
Journal:
Genet. in the 3rd Millenium
Year:
2010
Similar
MEDLINE
...
LILACS
LIS