study of plasma endotholin and nitric oxide in diabetic patients

ABSTRACT

The endothelin and nitric oxide considered a new system useful to understand and study the molecular mechanisms involved in aging process and in many vascular alteration pathologies. The study of this work was conducted on 65 subjects which divided into three groups. Group I It included 25 NIDDM, 14 male and 11 female. Group II. It included 25 IDDM, 14 male and 11 female. Group III It included 15 healthy subjects, 8 males and 7 females as control. The following investigation were done to all subjects: fasting and 2 hours PP plasma glucose level-Glycated hemoglobin urine analysis for microalbumin lipid profile plasma levels of endothelin and nitric oxide. The results of this study showed that significant increase in FB and PP blood sugar, cholesterol, triglycerides, LDL, microalbumin and endothelin with significant decreases in nitric oxide levels in both diabetic groups compared to controls. The result of previous parameters did, not differ significantly between both studied diabetic groups. Also these results showed that significant elevation endothelin and significant reduction of nitric oxide in poor controlled diabetic subjects as compared to controlled diabetic subjects. Conclusion plasma endothelin and nitric oxide levels could be added as chemical markers of diabetic control