Plasma homocysteine level in patients of coronary artery disease and its relation to vitamin B[12], folic ACID and other lipid risk factors

ABSTRACT

This study was planned to clarify the role of Homocysteine level in patients with coronary artery disease [CAD] in relation to folic acid and vitamin B[12], deficiency. The study included 90 persons; 20 healthy control, and 70 patients with [CAD], whom classified into [subgroup-1] included 25 cases of AMI, [subgroup-2] included 25 patients of unstable angina, and [subgroup-3] included 20 cases of stable angina. All cases in different groups and subgroups were underwent to coronary angiography at cardiology department of Al-Hussein university Hospital. Blood samples from all patients and control groups were analyzed at clinical pathology department at the same hospital for 1 - Serum total Homocysteine. 2-Serum vitamin B[12] and folic acid- 3-Serum total cholesterol, Triglyceride, LDL, HDL, CK, CK-MB and LDH. The study revealed that there was high significance difference between control group and each subgroup as regard elevation of homocysteine and reduction of folic acid and vitamin B[12]; P-value <0.0001. There was correlation between elevation of homocysteine and folic acid deficiency in all subgroups, p-value<0.05- Also, there was correlation between elevation of homocysteine and vitamin B[12] deficiency in all subgroups, P-value<0.05. There is direct relation between hyper-homocysteinemia, folic acid, vitamin B[12] deficiency and coronary artery disease. We advice administration combined therapy with folic acid and vitamin B[12] to high risk individual of CAD