EParasite density and morbidity in relation to serum levels of thrombomodulin and E-selectin in the acute phase of plasmodium vivax malaria

ABSTRACT

Standardized questionnaires, clinical examination and parasitological diagnosis were performed on 40 patients in the acute phase of vivax malaria from the out patient clinics, El Abbassia Fevers Hospital. Serum levels of Thrombomadulin [TM], E-selectin and creatinine were determined in inrolled patients and also in 20 healthy controls. The results, based on multivariable analysis, showed that the clinical diagnosis of malaria including history of fever, rigors, headache, myalgia and palpable spleen was strongly associated with the presence and density of P. vivax malaria even in patients with parasite densities less than l000/micro l of blood and significantly increased the odds of the clinical diagnosis. Results revealed also that the patient's mean +/- SD serum levels of TM and E-selectin were 12.8 +/- 3.67 and 125 +/- 61.4 [u/micro l] respectively, significantly greater than in the controls [TM, P<0.001, E-selectin, P<0.001]. However, no significant differences were identified between patients and controls for serum creatinine values. On the other hand, there was a high significant correlation between levels of parasitemia and serum levels of TM and E-selectin