Relationship between interleukin-6 levels and periodontal status of patients with insulin dependent diabetes mellitus and chronic periodontitis

ABSTRACT

The aim of the present study was to determine interleukjn-6 [IL-6] levels in gingival crevicular fluid [GCF] and serum and to compare the levels with clinical periodontal findings in patients with diabetes mellitus [DM] and chronic periodontitis [CP]. A total of 30 patients were divided into 3 groups [10 patient with DM and CP, 10 patients with CP and 10 healthy controls] Gingival index [GI] and pocket dopth [PD] values for each CP patients were recorded. Enzyme linked immunosorbent assay for quantitative detection of IL-6 in each GCF and serums sample was employed. Significant difference was detected between all groups with the lowest level of GCF IL-6 in DM/CP. However various IL-6 levels were detected in the serum of DM/CP group which failed to be assayed for CP and control group. No strong correlation could be detected between GCF IL-6 level and GI score or PD values. The finding of the present study suggests that IL-6 should not be considered as just an inflammatory mediator aiding in tissue destruction but it posses a pivotal role in tissue homeostasis To our knowledge this study is the first report correlating IL-6 levels in insulin dependent diabetes mellitus to their clinical periodontal data