Preliminary screening of pharmacological activities of E-3 arylidene flavanones

ABSTRACT

Objective of the present study was to synthesize E-3-arylidene flavanones by one pot method and screen their analgesic, anti-oxidant and anti-bacterial activities. A set of four E-3 arylidene flavanones were synthesized by simple base catalysed condensation of appropriate aryl aldehydes and 2'4'dihydroxy acetophenone. Screened analgesic activity by hot plate method, anti-oxidant activity by spectrophotometric method and anti-bacterial activity by cup-plate method. Result showed all four synthesized compounds were found to exhibit reliable degree of analgesic activity and antioxidant action produced by the synthesized compounds were in reverse order to that of analgesic activity. A few of synthesized compounds showed activity against some organisms. Even though all synthesized compounds have same basic nucleus, biological activities expressed by different compounds are not same. Due to structural similarity with those of natural flavanones, all the synthesized compounds were expected to exhibit analgesic activity, but only three were found to exhibit analgesic action. But all showed a reliable degree of anti-oxidant activity. In anti-bacterial studies unsubstituted compound didn't showed any kind of antibacterial activity against any of the tested organisms