Your browser doesn't support javascript.
loading
differences in the relaxant effects of different fractions of rosa damascena on guinea pig tracheal smooth muscle
Iranian Journal of Basic Medical Sciences. 2010; 13 (3): 126-132
in English | IMEMR | ID: emr-105479
ABSTRACT
In the present study, the differences in the relaxant effects of aqueous, ethyl acetate and n-butanol fractions of Rosa damascena on tracheal smooth muscle of guinea pigs were examined. The relaxant effects of three cumulative concentrations of each fraction [0.1, 0.2 and 0.4 g%] in comparison with saline and three cumulative concentrations of theophylline [0.1, 0.2, and 0.4 mM] were examined on precontracted tracheal chains of guinea pig by 60 mM KCl [group 1, n=5] and 10 micro M methacholine [group 2, n=8]. In group 1, all concentrations of theophylline, ethyl acetate fraction and two final concentrations of n-butanol fraction showed significant relaxant effects in comparison with saline [p< 0.05 to P< 0.001]. In group 2, all concentrations of theophylline, ethyl acetate and aqueous fractions showed concentration dependent relaxant effects compared to that of saline [p< 0.01 to P< 0.001]. In addition, the effect of ethyl acetate fraction in group 1 was significantly higher than those of theophylline [p< 0.05 to p< 0.001]. However, the effects of other fractions were significantly lower than theophylline in both groups [p< 0.01 to p< 0.001]. There were significant correlations between the relaxant effects and concentrations for theophylline and all fractions [except aqueous fractions in group 1] in both groups. The results showed a potent relaxant effect for ethyl acetate fraction of R. damascena on tracheal smooth muscle comparable to that of theophylline but a relatively weak relaxant effect for aqueous and n-butanol fractions at concentrations used
Subject(s)
Search on Google
Index: IMEMR (Eastern Mediterranean) Main subject: Plants, Medicinal / Trachea / Bronchodilator Agents / Plant Extracts / Butanols / Guinea Pigs / Muscle, Smooth Limits: Animals Language: English Journal: Iran. J. Basic Med. Sci. Year: 2010

Similar

MEDLINE

...
LILACS

LIS

Search on Google
Index: IMEMR (Eastern Mediterranean) Main subject: Plants, Medicinal / Trachea / Bronchodilator Agents / Plant Extracts / Butanols / Guinea Pigs / Muscle, Smooth Limits: Animals Language: English Journal: Iran. J. Basic Med. Sci. Year: 2010