<The> effect of snake venom metalloproteinase/disintegrin like activity on liver of albino white mice

Walid Said, Zaki; Salwa Saad, Lasheen; Ayman R., Basheer; Hanaa E., Nasser; Fathy M., Tash; Mohamed F., El Asmar

effect of snake venom metalloproteinase/disintegrin like activity on liver of albino white mice

Walid Said, Zaki; Salwa Saad, Lasheen; Ayman R., Basheer; Hanaa E., Nasser; Fathy M., Tash; Mohamed F., El Asmar.

EJB-Egyptian Journal of Biochemistry and Molecular Biology [The]. 2007; 25 (1): 37-58

in English | IMEMR | ID: emr-105933

ABSTRACT

ABSTRACT

This is a study on the effect of snake venom metalloproteinase/ Disintegrin like action [SVMP] purified from Cerastes cerastes venom on expression of TNF-alpha, and Heme-oxygenase-1 in white mice liver tissue injected intraperitoneally with the purified fraction. Hepato-protective effect of the fraction against some hepatotoxins as CCU was investigated histo-pathologically. This hepatoprotection coincides with expression of TNF-alpha and HO-1 genes in liver tissue. This study is supported by grant no. 28 from Professor Dr. M. F. EL-Asmar

Subject(s)

Animals, Laboratory; Matrix Metalloproteinase 1; Carbon Tetrachloride; Mice; Protective Agents; Electrophoresis, Agar Gel; Polymerase Chain Reaction; Liver/pathology; Histology; Disintegrins

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Index: IMEMR (Eastern Mediterranean) Main subject: Carbon Tetrachloride / Polymerase Chain Reaction / Disintegrins / Protective Agents / Matrix Metalloproteinase 1 / Electrophoresis, Agar Gel / Histology / Liver / Mice Limits: Animals Language: English Journal: Egypt. J. Biochem. Mol. Biol. Year: 2007

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