Alteration in circulating soluble Fas level in Toxoplasma seropositive pregnant women

ABSTRACT

The role of sFas in human toxoplasmosis was designed, included 23 pregnant women serologically positive for anti-Toxoplasma antibodies, and ten sero-negative pregnant females constituted the control group. Antibody titer was assessed by indirect haemagglutination test. The presence of specific IgM antibodies was determined by comparing antibody titer before and after serum treatment with 2-mercaptoethanol. sFas was quantified in sera of cases and controls by enzyme linked immunosorbent assay. Antibody titers ranged from 1/160 to 1/640. All cases were negative for specific IgM antibodies indicating that they had passed the acute stage of infection Statistical analysis revealed significant elevation in sFas level in cases compared to controls. The sFas role in establishment of a stable host parasite interaction in toxoplasmosis was discussed