study on certain hormonal disturbances in breast carcinoma

ABSTRACT

Seven hormones were studied in 23 cases of cancer breast 16 preoperative and 7 postoperative. The 7 hormones studied were GH, prolactin, T4, T3, ACTH, estrogen and progesterone. Ten matched controls were studied at the same time for comparison. No significant changes were noticed in GH and ACTH, in preoperative and postoperative T4 cases as compared with controls. Significant decrease was noted in preoperative T4 and prolactin and in both preoperative and postoperative in T3 cases and increase in progesterone and estrogen in preoperative and postoperative periods as compared with the control level. Also, GH and ACTH showed significant drop postoperatively as compared with the preoperative as well as control levels. T4 showed a marked decrease in preoperative cases as compared with normal controls and the level return to normal in postoperative period. Follow up of patients with breast carcinoma before and after surgery may have an important role for better understanding of such hormonal changes and thus helps in the study of biological behavior of tumors