1 and, 25-Dihydroxyvitamin D3 in acute leukaemias and lymphomas

ABSTRACT

1,25[OH]2 D3 was estimated, using a sensitive radioimmunoassay technique, in sera from 40 patients with recently diagnosed hematologic malignancies [10 [AML], 10 [ALL], 10 [NHL] and 10 [HD]] and 10 normal controls for comparison. All patients showed normal liver and kidney functions with normal serum calcium, phosphorus, PTH and calcitonin. Serum concentrations of 1,25 [OH]2 D3 were significantly lower than that for the control group [AML [16.1 pg/ml], ALL [18.1 pg/ml], NHL [19.6 pg/ml] and HD [21.5 pg/ml] versus 28.2 pg/ml for the control]. Moreover, the least serum concentrations of 1,25 [OH]2D3 were found in AML and ALL groups. No significant correlations were detected between serum calcium and 1,25[OH]2 D3 in any of the studied groups