Gene frequency and linkage disequilibrium within the HLA-DRB region in Egyptians using PCR-based reversed hybridization oligonucleotide genotyping
Journal of the Egyptian National Cancer Institute. 1997; 9 (1): 69-74
in English
| IMEMR
| ID: emr-106401
ABSTRACT
HLA class II alleles were studied in 278 Egyptians. Gene frequency as well as linkage [haplotypic association] between HLA-DRB1, HLA- DRB3, HLA-DRB4 and HLA-DRB5 types were defined. A new unexpected haplotype linked with DRB5 was also detected. It was concluded that PCR based reversed hybridization genotyping is a reliable technique for DNA- based HLA-DR typing. In addition, this specific population study has important implications for unrelated bone marrow and other organ donor registries in Egypt
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
HLA-DR Antigens
/
Linkage Disequilibrium
/
Polymerase Chain Reaction
/
Hybridization, Genetic
/
Nucleic Acid Hybridization
Limits:
Humans
Language:
English
Journal:
J. Egypt. Natl. Cancer Inst.
Year:
1997
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