Evolution of tigecycline resistance in Klebsiella pneumoniae in a single patient
Annals of Saudi Medicine. 2010; 30 (5): 404-407
in English
| IMEMR
| ID: emr-106456
ABSTRACT
Carbapenemase-producing Klebsiella pneumoniae infections carry serious clinical and infection-control implications. Isolates possessing such hydrolyzing enzymes have been described in the United States and around the world. Besides being resistant to carbapenems, they usually confer resistance to fluoroquinolones, piperacillin-tazobactam, and extended-spectrum cephalosporins. Tigecycline demonstrates in vitro activity against these organisms, but reported resistance raises concern about tigecycline use for these infections. We describe a carbapenemase-producing K pneumoniae evolving resistance to tigecycline in a 75-year-old male after a prolonged stay in a critical care unit
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Klebsiella pneumoniae
/
Minocycline
/
Anti-Bacterial Agents
Type of study:
Case report
Limits:
Humans
/
Male
Language:
English
Journal:
Ann. Saudi Med.
Year:
2010
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