Serum level of galectin-3 in patients with oral squamous cell carcinoma
MEJC-Middle East Journal of Cancer. 2010; 1 (2): 77-81
in English
| IMEMR
| ID: emr-106573
ABSTRACT
Galectin-3, a member of the family of beta-galactoside-binding animal lectins, has been implicated in tumor invasion and metastasis. Using an ELISA kit, we assessed the circulating levels of galectin-3 in sera from 40 oral squamous cell carcinoma [OSCC] patients and from 43 healthy controls. Serum galectin-3 levels in OSCC patients were significantly higher [5.1 +/- 2.5 ng/ml] when compared with healthy controls [2.6 +/- 3.07 ng/ml, P<0.0005]. There was no apparent correlation between serum galectin-3 concentration and clinico-pathological features such as stage, tumor size, nodal status, distant metastasis and histological grade. This result suggests that, in addition to other tests, measurement of serum galectin-3 concentrations can be utilized as an adjuvant test for establishing a diagnosis of OSCC
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Enzyme-Linked Immunosorbent Assay
/
Mouth Neoplasms
/
Carcinoma, Squamous Cell
/
Galectin 3
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Middle East J. Cancer
Year:
2010
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