Effects of praziquantel [biltricide] on healthy mice: II- Hepatobiochemical and hepato-renal histopathological studies

ABSTRACT

This work was designed in order to study the effect of praziquantel on some hepatobiochemical and hepatorenal histopathological changes of healthy mice treated with a single oral dose of 40 mg per kgm body weight. Forty mice were used in the experiment as a study group. Five of the treated mice and five controls were killed at different time intervals 24, 72 hours and then weekly for a period of 6 weeks. The obtained results revealed that significant changes of hepatoenzymes viz glutamic pyruvic transaminase [GPT], Alkaline phosphatase and acid phosphatase were appeared. Hepatolipogram was affected significantly. Not only that but hepatoelectrolytes were also interrupted during the period of experiment. On the other hand, no histopathological changes were detected in the liver and kidney tissues of the treated group as compared with the control