Synthesis of some mannich bases of 2-, 4- amino and 2,4-Diamino-6-Methylpyrimidines as potential biodynamic agents

ABSTRACT

The synthesis of certain Mannich bases of 2-, 4-amino, and 2, 4-diamino-6-methylpyrimidines and their antimicrobial and antileukemic activities are described. Likewise, application of the Mannich conditions to 2-amino-4-[p-hydroxyanilino]-, 4-amino-2-[p- hydroxyanilino]-, and 2-amino-4-[p-acetylanilino]-6-methylprimidines using piperazine as the secondary amine afforded the corresponding bis-Mannich bases