Cephalexin complexes with some 3d transition-metal ions
Journal of Drug Research of Egypt. 1987; 17 (1-2): 197-205
in English
| IMEMR
| ID: emr-107333
ABSTRACT
The protonation constants of cephalexin and the stability constants of its complexes with Fe [III], Cu [II], Ni [II] and Mn [II] have been determined by pH-metric titration in aqueous medium at 30 and 40 and 0.1 M ionic strength [KCI]. The metal-ligand formation constants [long beta 2] calculated, show the order as Fe [III]> Cu [II]> Ni [III]> Mn [II]. Thermodynamic parameters [delta G, delta H and delta S] calculated at 30C and 0.1 M ionic strength, show that the interaction of cephalexin and these metal ions is chelation-reaction between ionic species. Thus, the entropy change plays important role in giving the observed stability
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Protons
/
Thermodynamics
/
Drug Stability
/
Metals
Language:
English
Journal:
J. Drug Res. Egypt
Year:
1987
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