In vitro predictability, in vitro dissolution of theophyllin

ABSTRACT

Theophylline sustained release tablet, Quibron 300 mg, was tested by USP. rotating basket over a period of 12 hours. In vivo test was carried on over a period of 24 hours. The percent absorbed from the tablet correlate extremely well with dissolution profile over 12 hour period. It was proved that there is nearly a 11 correlation of in vitro and in vivo data