Some histopathological changes in immuno-suppressed mice infected with hymenolepis nana var fraterna

ABSTRACT

Immune-suppression in Swiss Albino mice infected with H. nana and induced by administration of high and low doses of hydrocortisone acetate caused superinfection of the gut with H. fraterna worms and cysticercoids. There was also dissemination of cysticercoids to the liver with marked cellular infiltration, necrosis and destruction of the liver parenchyma. The pathogenesis caused by the disease whether in the gut or the liver was much more aggravated in the group of mice injected with the high dose of the drug. The control group of mice showed only few number of normal worms and cysticercoids in the gut without any extra-intestinal spread of cysticercoids to other organs. The results are discussed with those of others at the international level