Effect of cimaterol-induced muscle hypertrophy on calcium-dependent proteinase and calpistatin activities in young lambs

ABSTRACT

The aim of the present study was to reveal the possible relationships between cimaterol-induced hypertrophy of skeletal muscle and the activity of micromolar -Ca2- dependent proteinase [uM CDP], millimolar - Ca2+ - dependent proteinase [mM CDP], and their specific inhibitor [calpastatin]. 200 mg /kg/day of Cimaterol in milk replacer for 21 days increased mM CDP. The increased activity of calpastatin indicated that Cimaterol-induced muscle hypertrophy may be attained in part by reduction of the proteolytic activity of myofibrillar protein