Influence of age on pharmacokinetcs of orally administered nitrofurantoin and furazolidone in buffalo
Journal of Drug Research of Egypt. 1991; 20 (1-2): 207-15
in English
| IMEMR
| ID: emr-107527
ABSTRACT
The present work aims at studying the disposition kinetics of single doses of nitrofurantoin [NFT] and furazolidone [FZ] in buffalos of different ages. The experiments were conducted on animals of 6-8 years, 2-12 months and less than 2 months old. The pharmacokinetic analysis of the determined levels of the two tested drugs during 24 hours following their administration has showed age-dependent variations. The rate constant of elimination [Kel] was decreasing with the increase of age with a consequent prolongation of the elimination half life [tB 1/2]. As a net result of the different induced changes in pharmacokinetics, the area under the plasma level curve has been markedly decreased in the young age animals. As a conclusion, dosage regimens of NFT and FZ in buffalo calves should be adjusted according to the age of the animals
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Administration, Oral
/
Age Factors
/
Furazolidone
Limits:
Animals
Language:
English
Journal:
J. Drug Res. Egypt
Year:
1991
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