Cytotoxicity of caffeine

ABSTRACT

Toxicity of caffeine was studied in vitro on two types of cells using the cell culture technique. The evaluated parameters were cell detachment and cell growth. Five concentrations of caffeine in the range of 2x10-6 to 2x10-2 M were tested. Similar patterns of cytotoxicity were observed on the used types of cells. Results were evaluated in comparison with the toxic potential of other chemical agents. According to the obtained results, caffeine may be classified as a substance of mild cell toxicity potential