bioequivalence study on two preparations of furosemide in health volunteers

ABSTRACT

The two products under evaluation as a test and reference were found to be pharmaceutically equivalent. They were subjected for in vivo evaluation in healthy volunteers for furosemide plasma levels, and urinary levels and excretion rate of sodium where the computed relative bioavailability were 98.36% and 93.45% for furosemide plasma levels and urinary excretion of sodium, respectively. The needs and advantages of utilizing sodium determination in urine as an adjunct for bioequivalence measurements were discussed