Synthesis and antimicrobial activity of 3,5-bis- [1-3,4-oxadiazol-5-yl] -, [1,3-thiazolo] hydrazony1-and [7H] s-Triazolo- [3,4-b] -1,3,4 Thiadiazinyl] pyridine derivatives
Egyptian Journal of Chemistry. 1997; 40 (5): 365-74
in English
| IMEMR
| ID: emr-107828
ABSTRACT
Different 3, 5-bis [oxadiazolyl] pyridine derivatives 3-5 have been obtained from 1 depending on the reaction condition. Reaction of 5 with amines or alkylhalides afforded the corresponding Mannich bases 6 or s-alkyl derivatives 7. The latter derivatived were treated with ammonium acetate to give 9 and with hydrazine hydrate affording bis bicyclic pyridine derivatives 10. Preliminary antimicrobial tests showed products 6e and 8 to possess higher activity when compared with oxytetracycline
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Oxadiazoles
/
Pyridines
Language:
English
Journal:
Egypt. J. Chem.
Year:
1997
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