effects of some prostaglandin synthesis inhibitor drugs on serum glucose and insulin levels in diabetic patients

ABSTRACT

The effect of conventional doses of prostaglandin synthesis inhibitors [FGSIS] on serum glucose and insulin levels was studied in 30 diabetic patients. The results show that treatment with aspirin [one gram tds] for three days did not cause a significant change in fasting serum glucose and insulin levels, but it caused a significant drop in serum glucose and elevation in serum insulin following glucose load. Mefenamic acid [250 mg tds] given for three days did not alter significantly the fasting serum glucose or insulin and it did not change the serum glucose or insulin levels following glucose load. Diclofenac [25 mg tds] given for three days again did not alter fasting serum glucose or insulin and it did not affect significantly the serum glucose or insulin levels following the glucose loads