Endometrial response to exogenous ethinyl oestradiol in the normal and ovariectomized albino rat

ABSTRACT

Forty adult albino rats weighting 200-300 gm. were used. They were divided into 4 groups, each contains 10 animals. Animals of group I used as control group II received a daily oral dose of ethinyl estradiol for 3 weeks, group III exposed to bilateral ovariectomy and group IV were exposed to bilateral ovariectomy and received the same daily oral dose of the drug. At the end of the 3rd week the animals were sacrificed and the uteri were taken and processed for light microscopic study. Measurement for the endometrium and their lining epithelial cells were taken and analyzed. In non-ovariectomized treated rats, the endometrium showed many folds with tall columnar epithelial lining. The endometrial glands became numerous and enlarged. The histological changes in endometrium of normal treated rats were more extensive than that of the ovariectomized treated ones. Discussion of these results was done