Comparative study of combined therapy in simple obesity

ABSTRACT

Drug combinations used in small doses are as effective as full doses of individual drugs and produce less side effects. In term of potency, combination of fenfluramine and metformin in the most potent, but in term of absence of tolerance combination of diethyl propion and metformin is the least one to produce tolerance and is the best one to maintain the reduction in body weight. Fenfluramine and metformin combination is the best to be used in android obesity as it produces a significant reduction in W/H ratio which is also well correlated with the reduction in body mass index. Furthermore, it produces a significant reduction in subcutaneous fat [as measured by triceps skin fold and mid arm thickness]. So, a homogenous body fat redistribution can be achieved. The improvement in health indices [blood sugar, serum cholesterol, triglycerides and exercise tolerance] is well correlated with the reduction in body weight. Fenfluramine and metformin combination produces a highly significant improvement in blood sugar so this combination is good for diabetic obese, while fenfluramine and thyroid hormone combination produces significant improvement in serum cholesterol and triglycerides