Lipid peroxidation and malondialdehyde in synovial fluid and serum of patients with rheumatoid arthritis

ABSTRACT

The concentration of malondialdehyde in serum and syovial fluid was measured as an indicator of free radical in 20 arthritic patients [10 osteoarthritis and 10 rheumatoid arthritis] plus ten healthy volunteers. Free radical activity showed high significant increase in rheumatoid group compared with both control and osteoarthritic groups, this increase was manifested both in serums as well as in synovial fluid. From this study it is concluded that, measurement of free radicals are useful in diagnosis of rheumatoid arthritis. The study strongly recommend the administration of antioxidants side by side with antirheumatic drugs to correct the oxidative stress and promote oxidant antioxidant balance